DMT, or N,N-Dimethyltryptamine, is a naturally occurring psychedelic drug. It is derived from certain plants. Modern formulations of DMT are usually in the form of a crystalline powder which is smoked or injected. When DMT is combined with an MAOI (monoamine oxidase inhibitor), DMT is orally active and can be ingested by mouth.
DMT drug abuse results in a short, intense psychedelic high. When DMT is smoked or injected, peak concentrations of the drug occur immediately and last about 10 minutes. When DMT is combined with an MAOI, the MAOI prevents DMT from being broken down in the digestive system, so it can be taken orally and is also more potent. Oral ingestion of DMT produces a long lasting (over 3 hours) psychedelic experience.
DMT drug abuse causes intense visuals, euphoria and hallucinations. As with most hallucinogenic, the psychological effects of DMT drug abuse can be damaging. It can cause overwhelming fear and inability to distinguish reality. DMT is more potent than other hallucinogens, so DMT drug abuse can have more intense psychological effects. DMT can also trigger latent mental illness in someone who is already predisposed.
DMT itself does not have many physical side effects. DMT drug abuse can cause slightly elevated blood pressure, heart rate, pupil diameter, and rectal temperature. However, orally active DMT (DMT plus and MAOI) can be very dangerous, particularly when it is mixed with other drugs. MAOI’s interact with many other medications, illicit substances, supplements, even food, and the effect can be deadly. Those that engage in DMT drug abuse should never mix DMT with any other substance. MAO inhibitors may intensify and prolong the effects of other drugs such as central nervous system depressants, narcotic analgesics (painkillers), anticholinergic, and antidepressants. Other substances that can interact with DMT are: sedatives, tranquilizers, antihistamines, narcotics and alcohol, any of which can cause severe blood pressure drop. Those engaging in DMT drug abuse should also not combine oral DMT and amphetamines (even diet pills), mescaline, asarone, nutmeg, macromerine, ephedrine, oils of dill, parsley or wild fennel, beer, wine, cocoa, aged cheese, any of which can cause severe blood pressure rise.
DMT drug abuse has a low physical addiction potential, but it can be psychologically addicting. Physical tolerance to the drug builds up very rapidly and goes away almost as quickly. If you do not ingest enough of the drug during the first 30 seconds of DMT drug abuse, you will not be able to intensify the effect by further using. The body quickly becomes tolerant to DMT. However, in an hour, the tolerance dissipates, and you will once more be susceptible to the effects of the drug.
DMT drug abuse is illegal in the United States and most of the developed world. However, some religious institutions use DMT- containing ayahuasca tea to induce a spiritual experience. Some churches have successfully lobbied the Supreme Court to provisionally allow the use of ayahuasca in religious ceremonies. The Brazilian church União do Vegetal and the Santo Daime church have been given clearance to make and distribute ayahuasca under certain circumstances.